CD8 alpha anticorps (C-Term, Cytoplasmic Domain)

N° du produit ABIN7449043

Cet anticorps Souris Monoclonal détecte spécifiquement CD8 alpha dans FACS, IHC et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour CD8 alpha anticorps (C-Term, Cytoplasmic Domain) (ABIN7449043)

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 alpha est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: C8-144B

Détail du produit anti-CD8 alpha anticorps

Épitope: C-Term, Cytoplasmic Domain

Fonction: Mouse anti-CD8 alpha Monoclonal Antibody, Purified [C8/144B]

Purification: Purified

Immunogène: A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of alpha chain of human CD8 molecule

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:100 to 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IHC: 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CD8 alpha

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Autre désignation: CD8 alpha

Sujet: Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].

ID gène: 925

NCBI Accession: NP_001759

UniProt: P01732

Pathways: TCR Signaling